CMKLR1 Antibody

Polyclonal Antibody

CMKLR1

CHEMERINR antibody, Chemokine like receptor 1 antibody, Chemokine-like receptor 1 antibody, CHEMR23 antibody, CMKLR1 antibody, CML1_HUMAN antibody, DEZ antibody, G protein coupled receptor ChemR23 antibody, G protein coupled receptor DEZ antibody, G-protein coupled receptor ChemR23 antibody, G-protein coupled receptor DEZ antibody, Orphan G protein coupled receptor antibody, Orphan G protein coupled receptor Dez antibody, Resolvin E1 receptor antibody, RVER1 antibody

Synthesized peptide derived from internal of human CMKLR1.

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

Methner A., Biochem. Biophys. Res. Commun. 233:336-342(1997).
Samson M., Eur. J. Immunol. 28:1689-1700(1998).
Hillman R.T., Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Signal Transduction

Synthesized peptide derived from internal of Human CMKLR1.