CAMK2G/CAMK2B Antibody

ELISA, WB; WB:1:500-1:3000

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Synthesized peptide derived from C-terminal of human CaMK2beta/gamma.

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca2+ transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.

Deloukas P., Nature 429:375-381(2004).
Breen M.A., Biochem. Biophys. Res. Commun. 236:473-478(1997).
Tombes R.M., Biochim. Biophys. Acta 1355:281-292(1997).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Neuroscience

Synthesized peptide derived from C-terminal of Human CaMK2β/γ .