EPHA7 Antibody

EPHA7

Cek 11 antibody; Developmental kinase 1 antibody; EBK antibody; EHK-3 antibody; EHK3 antibody; EK11 antibody; Embryonic brain kinase antibody; EPH homology kinase 3 antibody; EPH-like kinase 11 antibody; Epha7 antibody; EPHA7_HUMAN antibody; Ephrin receptor Eph A7 antibody; Ephrin type A receptor 7 antibody; Ephrin type-A receptor 7 antibody; hEK11 antibody; MDK 1 antibody; Receptor protein tyrosine kinase HEK 11 antibody; Tyrosine protein kinase receptor EHK 3 antibody

Synthesized peptide derived from internal of human EPHA7.

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Fox G.M., Oncogene 10:897-905(1995).
Mungall A.J., Nature 425:805-811(2003).
Sjoeblom T., Science 314:268-274(2006).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cardiovascular

Synthesized peptide derived from internal of Human EPHA7.