Hersteller |
Cusabio
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human, Mouse, Rat |
Isotype |
IgG |
Format |
Liquid |
Applikationen |
WB, IHC, ELISA |
Menge |
100ul |
Host |
Rabbit |
ArtNr |
CSB-PA271293 |
Targets |
MAPT |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Alias |
AI413597 antibody; AW045860 antibody; DDPAC antibody; FLJ31424 antibody; FTDP 17 antibody; G protein beta1/gamma2 subunit interacting factor 1 antibody; MAPT antibody; MAPTL antibody; MGC134287 antibody; MGC138549 antibody; MGC156663 antibody; Microtubule associated protein tau antibody; Microtubule associated protein tau isoform 4 antibody; Microtubule-associated protein tau antibody; MSTD antibody; Mtapt antibody; MTBT1 antibody; MTBT2 antibody; Neurofibrillary tangle protein antibody; Paired helical filament tau antibody; Paired helical filament-tau antibody; PHF tau antibody; PHF-tau antibody; PPND antibody; PPP1R103 antibody; Protein phosphatase 1, regulatory subunit 103 antibody; pTau antibody; RNPTAU antibody; TAU antibody; TAU_HUMAN antibody; Tauopathy and respiratory failure antibody; Tauopathy and respiratory failure, included antibody, MAPT, MTAPT, MTBT1, Neurofibrillary tangle protein, PHF-tau |
Immunogen Species |
Human |
UniprotID |
P10636 |
Immunogen |
Peptide sequence around phosphorylation site of threonine 205 (P-G-T(p)-P-G) derived from Human Tau. |
Applications info |
ELISA, WB, IHC, WB:1:500-1:1000, IHC:1:50-1:100 |
Dilution ratio 1 |
ELISA:1:2000-1:10000 |
Dilution ratio 2 |
WB:1:500-1:1000 |
Dilution ratio 3 |
IHC:1:50-1:100 |
Background |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
del C Alonso A, et al. (2004) J Biol Chem, 279(33): 34873-81 Li G, Yin H, Kuret J (2004) J Biol Chem, 279(16): 15938-45 Giasson BI, et al. (2002) Biochemistry, 41(51): 15376-87 Liu F, et al. (2002) FEBS Lett, 530(1-3): 209 Taniguchi T, et al. (2001) J Biol Chem, 276(13): 10025-31 |
Conjugate |
Non-conjugated |
Buffer |
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Storage |
Upon receipt, store at -20C or -80C. Avoid repeated freeze. |
Purification Method |
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
General Research Areas |
Neuroscience, Signal transduction |
Initial Research Areas |
Neuroscience |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.