Phospho-MAPKAPK2 (Thr334) Antibody

Polyclonal Antibody

MAPKAPK2

MAP kinase activated protein Kinase 2 antibody, MAP kinase-activated protein kinase 2 antibody, MAPK activated protein kinase 2 antibody, MAPK-activated protein kinase 2 antibody, MAPK2_HUMAN antibody, MAPKAP K2 antibody, MAPKAP kinase 2 antibody, MAPKAPK 2 antibody, MAPKAPK-2 antibody, MAPKAPK2 antibody, Mitogen activated protein kinase activated protein kinase 2 antibody, MK 2 antibody, MK2 antibody

Peptide sequence around phosphorylation site of threonine 334 (P-Q-T(p)-P-L) derived from Human MAPKAPK-2.

MAPKAPK-2 encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.

Rouse, J. et al. (1994) Cell 78, 1027-1037.
Ben-Levy, R. et al. (1995) EMBO J. 14, 5920-5930.

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Cardiovascular

Peptide sequence around phosphorylation site of threonine 334 (P-Q-T(p)-P-L) derived from Human MAPKAPK-2.