RRAGA/RRAGB Antibody

ELISA, WB; WB:1:500-1:3000

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Synthesized peptide derived from internal of human RRAGA/B.

Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Schuermann A., J. Biol. Chem. 270:28982-28988(1995).
Li Y., J. Virol. 71:1576-1582(1997).
Hirose E., J. Cell Sci. 111:11-21(1998).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Microbiology

Synthesized peptide derived from internal of Human RRAGA/B.