Phospho-HDAC8 (Ser39) Antibody

Polyclonal Antibody

HDAC8

CDA07 antibody, CDLS5 antibody, HD 8 antibody, HD8 antibody, HDAC 8 antibody, Hdac8 antibody, HDAC8_HUMAN antibody, HDACL 1 antibody, HDACL1 antibody, Histone deacetylase 8 antibody, Histone deacetylase like 1 antibody, MRXS6 antibody, RPD 3 antibody, RPD3 antibody, WTS antibody

Peptide sequence around phosphorylation site of serine 39 (R-A-S(p)-M-V) derived from Human HDAC8.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC8 gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

Lee H, et al. (2004) Mol Cell Biol. 24(2): 765-773.

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Epigenetics and Nuclear Signaling

Peptide sequence around phosphorylation site of serine 39 (R-A-S(p)-M-V) derived from Human HDAC8.