EFNA5 Antibody

EFNA5

EPLG7 antibody; AF1 antibody; AL 1 antibody; AL-1 antibody; EFL5 antibody; Efna5 antibody; EFNA5_HUMAN antibody; EPH-related receptor tyrosine kinase ligand 7 antibody; Ephrin A5 antibody; Ephrin-A5 antibody; EPLG7 antibody; GLC1M antibody; LERK-7 antibody; LERK7 antibody; RAGS antibody

Synthesized peptide derived from internal of human EFNA5.

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

Winslow J.W., Neuron 14:973-981(1995).
Kozlosky C.J., Cytokine 9:540-549(1997).
Davy A., Genes Dev. 13:3125-3135(1999).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Neuroscience

Synthesized peptide derived from internal of Human EFNA5.