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CSK Monoclonal Antibody

ArtNr CSB-MA199199
Hersteller Cusabio
Menge 100 ul
Kategorie
Typ Antibody Monoclonal
Format Liquid
Applikationen WB, ICC, ELISA
Clon 6B9
Specific against Human (Homo sapiens), Rat (Rattus norvegicus)
Host Mouse
Isotype IgG2b
Konjugat/Tag Unconjugated
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias C SRC; C SRC kinase; C src Tyrosine Kinase; C-SRC kinase; c-src tyrosine kinase; Csk A; CSK; CSK_HUMAN; CYTOPLASMIC TYROSINE KINASE; EC2.7.10.2; MGC112926; MGC117393; MGC154049; P60 Src; Protein tyrosine kinase CYL; Protein-tyrosine kinase CYL;
Similar products CSK, Protein-tyrosine kinase CYL, MGC117393, C SRC, C SRC kinase, C src Tyrosine Kinase, C-SRC kinase, c-src tyrosine kinase, Csk A, CSK_HUMAN, CYTOPLASMIC TYROSINE KINASE, MGC112926, MGC154049, P60 Src, Protein tyrosine kinase CYL, EC2.7.10.2
Lieferbar
Manufacturer - Type
Hybridoma Monoclonal Antibody
Manufacturer - Targets
CSK
Storage Conditions
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Immunogen Species
Human
Immunogen
Purified recombinant human CSK protein fragments expressed in E.coli.
Dilution
WB:1:500-1:5000, ICC:1:50-1:200
Buffer
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine(pH 7.4, 150 mM NaCl)with 0.2% sodium azide, 0.1mg/mlBSA and 50% glycerol.
Purification Method
Affinity purified
General Research Areas
Signal Transduction
Initial Research Areas
Signal Transduction
Relevance
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Antigen Species
Human
Antigen
Purified recombinant human CSK protein fragments expressed in E.coli.
Clonality
Monoclonal

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ul
Lieferbar: In stock
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