Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1),partial

CEACAM1

E.coli

P13688

N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged

Extracellular Domain

Biliary glycoprotein 1
Short name:BGP-1

Greater than 90% as determined by SDS-PAGE.

Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.

Isoform 1: Cell membrane, Single-pass type I membrane protein, Lateral cell membrane, Apical cell membrane, Basal cell membrane, Cell junction, Cell junction, adherens junction, Note=Canalicular domain of hepatocyte plasma membranes, Found as a mixture of monomer, dimer and oligomer in the plasma membrane, Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions, Found as dimer in the solution, Predominantly localized to the lateral cell membranes, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Isoform 3: Secreted, SUBCELLULAR LOCATION: Isoform 4: Secreted, SUBCELLULAR LOCATION: Isoform 5: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 6: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 7: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 8: Cell membrane, Single-pass type I membrane protein, Cytoplasmic vesicle, secretory vesicle membrane, Lateral cell membrane, Apical cell membrane, Basal cell membrane, Cell junction, Cell junction, adherens junction, Note=Predominantly localized to the lateral cell membranes, Found as a mixture of monomer, dimer and oligomer in the plasma membrane, Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions (By similarity), Co-localizes with ANXA2 in secretory vesicles and with S100A10/p11 at the plasma membrane (PubMed:14522961), SUBCELLULAR LOCATION: Cell projection, microvillus membrane, Single-pass type I membrane protein, Apical cell membrane, Single-pass type I membrane protein

The predominant forms expressed by T cells are those containing a long cytoplasmic domain (PubMed:18424730). Expressed in granulocytes and lymphocytes. Leukocytes only express isoforms 6 and isoform 1 (PubMed:11994468).