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Recombinant Human Orexin receptor type 1(HCRTR1),partial

Recombinant Human Orexin receptor type 1(HCRTR1),partial

Hersteller	Cusabio
Kategorie	Neuroscience Neural Lineage Markers Metabolism Glucose Homeostasis Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	other
Format	Liquid or Lyophilized powder
Menge	1mg
ArtNr	CSB-EP010231HU1-1
Konjugat/Tag	Myc
eClass 6.1	34160400
eClass 9.0	42020190
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Research Areas	Metabolism
Uniprot ID	O43613
Gene Names	HCRTR1
Organism	Homo sapiens (Human)
AA Sequence	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYL WRDYLYPKQYE
Expression Region	1-46aa
Sequence Info	Partial
Source	E.coli
Tag Info	N-terminal 10xHis-tagged and C-terminal Myc-tagged
MW	10.4 kDa
Alternative Name(s)	Hypocretin receptor type 1
Relevance	Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca2+ levels in response to orexin-A binding
Reference	Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors. Yin J., Babaoglu K., Brautigam C.A., Clark L., Shao Z., Scheuermann T.H., Harrell C.M., Gotter A.L., Roecker A.J., Winrow C.J., Renger J.J., Coleman P.J., Rosenbaum D.M. Nat. Struct. Mol. Biol. 23:293-299(2016)
Purity	Greater than 85% as determined by SDS-PAGE.
Form	Liquid or Lyophilized powder
Buffer	If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20C/-80C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide
Subcellular Location	Cell membrane, Multi-pass membrane protein
Protein Families	G-protein coupled receptor 1 family
Tag Information	N-terminal 10xHis-tagged and C-terminal Myc-tagged

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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