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Recombinant Mouse 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr),partial

Recombinant Mouse 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr),partial

Hersteller	Cusabio
Kategorie	Metabolism Cholesterol & Lipid Metabolism Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	other
Format	Liquid or Lyophilized powder
Menge	500ug
ArtNr	CSB-EP010565MO1-500
eClass 6.1	34160400
eClass 9.0	42020190
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Research areas	Cardiovascular
Target / Protein	Hmgcr
Biologically active	Not Test
Expression system	E.coli
Species of origin	Mus musculus (Mouse)
Uniprot ID	Q01237
AA Sequence	GRGKTVVCEAVIPAKVVREVLKTTTEAMVDVNINK NLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQ NVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTV GGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR IVCGTVMAGELSLMAALAAGH
Tag Info	N-terminal 6xHis-tagged
Expression Region	700-860aa
Protein length	Partial
MW	20.4 kDa
Relevance	Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
References	"Glucocorticoid-regulated gene expression in the immune system. Analysis of glucocorticoid-regulated transcripts from the mouse macrophage-like cell line P388D1." Helmberg A., Faessler R., Geley S., Joehrer K., Kroemer G., Boeck G., Kofler R. J. Immunol. 145:4332-4337(1990)
Purity	Greater than 85% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Subcellular Location	Endoplasmic reticulum membrane, Multi-pass membrane protein
Protein Families	HMG-CoA reductase family
Tag Information	N-terminal 6xHis-tagged

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