Hersteller |
Cusabio
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Menge |
50ug |
Host |
E.coli |
ArtNr |
CSB-EP014706HU-50 |
Konjugat/Tag |
GST |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Research Topic |
Signal Transduction |
Uniprot ID |
O96007 |
Gene Names |
MOCS2 |
Organism |
Homo sapiens (Human) |
AA Sequence |
MSSLEISSSCFSLETKLPLSPPLVEDSAFEPSRKD MDEVEEKSKDVINFTAEKLSVDEVSQLVISPLCGA ISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRK ICSDIRQKWPVKHIAVFHRLGLVPVSEASIIIAVS SAHRAASLEAVSYAIDTLKAKVPIWKKEIYEESST WKGNKECFWASNS |
Expression Region |
1-188aa |
Sequence Info |
Full Length |
Source |
E.coli |
Tag Info |
N-terminal GST-tagged |
MW |
47.9 kDa |
Alternative Name(s) |
MOCO1-B Molybdenum cofactor synthesis protein 2 large subunit Molybdenum cofactor synthesis protein 2B |
Relevance |
Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. |
Reference |
"Human molybdopterin synthase gene: identification of a bicistronic transcript with overlapping reading frames." Stallmeyer B., Drugeon G., Reiss J., Haenni A.L., Mendel R.R. Am. J. Hum. Genet. 64:698-705(1999) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. |
Involvement in disease |
Molybdenum cofactor deficiency, complementation group B (MOCODB) |
Subcellular Location |
Cytoplasm, cytosol |
Protein Families |
MoaE family, MOCS2B subfamily |
Tissue Specificity |
Highest levels are found in heart and skeletal muscle. Lower levels are present in brain, kidney and pancreas. Very low levels are found in lung and peripheral blood leukocytes. |
Tag Information |
N-terminal GST-tagged |
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