Hersteller |
Cusabio
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Menge |
500ug |
Host |
E.coli |
ArtNr |
CSB-EP015688HU-500 |
Konjugat/Tag |
Myc |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Research areas |
others |
Target / Protein |
NEFL |
Biologically active |
Not Test |
Expression system |
E.coli |
Species of origin |
Homo sapiens (Human) |
Uniprot ID |
P07196 |
AA Sequence |
SSFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTA RSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENL DLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIE RVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQ EIRDLRLAAEDATNEKQALQGEREGLEETLRNLQA RYEEEVLSREDAEGRLMEARKGADEAALARAELEK RIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVE MDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFK SRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKT LEIEACRGMNEALEKQLQELEDKQNADISAMQDTI NKLENELRTTKSEMARYLKEYQDLLNVKMALDIEI AAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGR SAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEE TIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEA AEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEE EKKVEGAGEEQAAKKKD |
Tag Info |
N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged |
Expression Region |
2-543aa |
Protein length |
Full Length of Mature Protein |
MW |
81.4 kDa |
Alternative Name(s) |
68 kDa neurofilament protein Neurofilament triplet L protein |
Relevance |
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. |
References |
"The structure of a human neurofilament gene (NF-L): a unique exon-intron organization in the intermediate filament gene family."Julien J.-P., Grosveld F., Yazdanbaksh K., Flavell D., Meijer D., Mushynski W.Biochim. Biophys. Acta 909:10-20(1987) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Neurofilaments usually contain three intermediate filament proteins |
Involvement in disease |
Charcot-Marie-Tooth disease 1F (CMT1F); Charcot-Marie-Tooth disease 2E (CMT2E) |
Protein Families |
Intermediate filament family |
Tag Information |
N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged |
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