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Recombinant Human Regulator of G-protein signaling 20(RGS20)

Recombinant Human Regulator of G-protein signaling 20(RGS20)

Hersteller	Cusabio
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	other
Format	Liquid or Lyophilized powder
Menge	500ug
Host	E.coli
ArtNr	CSB-EP019652HU-500
Konjugat/Tag	GST
eClass 6.1	34160400
eClass 9.0	42020190
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Research Topic	Signal Transduction
Uniprot ID	O76081
Gene Names	RGS20
Organism	Homo sapiens (Human)
AA Sequence	EPAGASSPAGRVDGGLQMGSERMEMRKRQMPAAQD TPGAAPGQPGAGSRGSNACCFCWCCCCSCSCLTVR NQEDQRPTIASHELRADLPTWEESPAPTLEEVNAW AQSFDKLMVTPAGRNAFREFLRTEFSEENMLFWMA CEELKKEANKNIIEEKARIIYEDYISILSPKEVSL DSRVREVINRNMVEPSQHIFDDAQLQIYTLMHRDS YPRFMNSAVYKDLLQSLSEKSIEA
Expression Region	1-234aa
Sequence Info	Full Length of BC015614
Source	E.coli
Tag Info	N-terminal GST-tagged
MW	53.4 kDa
Alternative Name(s)	Gz-selective GTPase-activating protein
Relevance	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins
Reference	"RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz GTPase-activating protein subfamily." Wang J., Ducret A., Tu Y., Kozasa T., Aebersold R., Ross E.M. J. Biol. Chem. 273:26014-26025(1998)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
Subcellular Location	Membrane, Lipid-anchor, Nucleus, Cytoplasm
Tissue Specificity	Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe.
Tag Information	N-terminal GST-tagged

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