Hersteller |
Cusabio
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Menge |
50ug |
Host |
E.coli |
ArtNr |
CSB-EP326235DBI-50 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Research Topic |
Others |
Uniprot ID |
P25687 |
Gene Names |
N/A |
Organism |
Dendroaspis polylepis polylepis (Black mamba) |
AA Sequence |
AVITGACERDLQCGKGTCCAVSLWIKSVRVCTPVG TSGEDCHPASHKIPFSGQRMHHTCPCAPNLACVQT SPKKFKCLSKS |
Expression Region |
1-81aa |
Sequence Info |
Full Length |
Source |
E.coli |
Tag Info |
N-terminal 6xHis-SUMO-tagged |
MW |
24.6 kDa |
Alternative Name(s) |
Short name: MIT 1 Alternative name(s): Black mamba intestinal toxin 1 Black mamba venom protein A |
Relevance |
Potently contracts gastrointestinal (GI) smooth muscle. The receptor for this toxin is present both in the CNS and in the smooth muscle and may be a potassium channel. |
Reference |
"MIT1, a black mamba toxin with a new and highly potent activity on intestinal contraction."Schweitz H., Pascaud P., Diochot S., Moinier D., Lazdunski M.FEBS Lett. 461:183-188(1999) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2 |
Subcellular Location |
Secreted |
Protein Families |
AVIT (prokineticin) family |
Tissue Specificity |
Expressed by the venom gland. |
Tag Information |
N-terminal 6xHis-SUMO-tagged |
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