Recombinant Human RuvB-like 2(RUVBL2)

Epigenetics and Nuclear Signaling

Not Test

Homo sapiens (Human)

ATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDA LEPRQASQGMVGQLAARRAAGVVLEMIREGKIAGR AVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGS EIFSLEMSKTEALTQAFRRSIGVRIKEETEIIEGE VVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGT KMIESLTKDKVQAGDVITIDKATGKISKLGRSFTR ARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHE IDVINSRTQGFLALFSGDTGEIKSEVREQINAKVA EWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRAL ESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLL DRLLIVSTTPYSEKDTKQILRIRCEEEDVEMSEDA YTVLTRIGLETSLRYAIQLITAASLVCRKRKGTEV QVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELK GETMDTS

2-463aa

67 kDa

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.
Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes.

Greater than 90% as determined by SDS-PAGE.

Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.

Nucleus matrix, Nucleus, nucleoplasm, Cytoplasm, Membrane

Ubiquitously expressed. Highly expressed in testis and thymus.