Hersteller |
Cusabio
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Menge |
1mg |
Host |
Yeast |
ArtNr |
CSB-YP525079MQZ-1 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Research Topic |
Allergen |
Uniprot ID |
O49894 |
Gene Names |
N/A |
Organism |
Annual mercury |
AA Sequence |
MSWQTYVDDHLMCDIDGQGQHLAAASIVGHDGSIW AQSASFPQLKPEEITGIMKDFDEPGHLAPTGLYIA GTKYMVIQGESGAVIRGKKGSGGITIKKTGQALVF GIYEEPVTPGQCNMVVERLGDYLIEQGM |
Expression Region |
1-133aa |
Sequence Info |
Full Length |
Source |
Yeast |
Tag Info |
N-terminal 6xHis-tagged |
MW |
16.3 kDa |
Alternative Name(s) |
Pollen allergen Mer a 1 Allergen: Mer a 1 |
Relevance |
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG |
Reference |
"Characterization of recombinant Mercurialis annua major allergen Mer a 1 (profilin)."Vallverdu A., Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez A., Martinez J., Palacios R.J. Allergy Clin. Immunol. 101:363-370(1998) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity). |
Subcellular Location |
Cytoplasm, cytoskeleton |
Protein Families |
Profilin family |
Tag Information |
N-terminal 6xHis-tagged |
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