Hersteller |
Enogene
|
Kategorie |
|
Typ |
Antibody |
Specific against |
Human |
Applikationen |
ELISA, Western Blot |
Menge |
100ug/100ul |
Host |
Mouse |
ArtNr |
E10-20278 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Background |
F8. coagulation factor VIII, procoagulant component. This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. |
Research Area |
Autophagy antibody, Cancer, Cardiovascular, Cell Biology, Epigenetics and Nuclear Signaling, Developmental Biologys, Immunology, Drug Discovery Products, Metabolism, Neuroscience, Signal Transduction, Stem Cells |
Form of Antibody |
Ascitic fluid containing 0.03% sodium azide. |
Altername |
AHF, F8B, F8C, HEMA, FVIII |
Immunogen |
Purified recombinant fragment of F8 expressed in E. Coli. |
Applications information |
WB, ELISA. Not yet tested in other applications. Determining optimal working dilutions by titration test. |
Recommended Dilutions |
WB.1/500 - 1/2000.ELISA. Propose dilution 1/10000. |
Storage/Stability |
Store at 4C, for long term storage, store at -20C |
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