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PCSK9/Proprotein Convertase 9

PCSK9/Proprotein Convertase 9

ArtNr	E21-A83
Hersteller	Enogene
Menge	10 ug
Kategorie	Oncology Neuroscience Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Neural Adhesion Molecules By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Obesity Lipoprotein Receptors & Associated Proteins Cardiovascular Research Ischemia & Reperfusion Injury By Organ Bladder Cancer
Typ	Proteins
Format	Liquid
Specific against	Human (Homo sapiens)
Host	Human
Purity	Greater than 95% as determined by reducing SDS-PAGE.
Dry ice	Yes
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Proprotein Convertase Subtilisin/Kexin Type 9,Neural Apoptosis-Regulated Convertase 1,NARC-1,Proprotein Convertase 9,PC9,Subtilisin/Kexin-Like Protease PC9,PCSK9,NARC1
Lieferbar
Manufacturer - Host	Human cells
Shipping Temperature	The product is shipped on dry ice/ice packs. Dry Ice/ice packs
Storage Conditions	Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Background	Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.
Description	Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln152&Ser153-Gln692 is expressed with a 6His tag at the C-terminus.
Endotoxin	Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Formulation Description	Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20%Glycerol, pH 7.4.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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E21-A83-datasheet.pdf

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Menge: 10 ug

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Lieferung vsl. bis 23.10.2025

Express-Lieferung: 24 Tage sparen

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