Background |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeabilityfactor (VPF), is a member of the PDGF family and often exists as a disulfide-linked homodimer. VEGF is expressed in a variety of tissues as multiple homodimeric forms (121, 165, 189, and 206 amino acids/monomer) resulting from alternative RNA splicing. It binds the type I transmembrane receptor tyrosine kinases VEGF R1 (also called Flt1) and VEGF R2 (Flk1/KDR) on endothelial cells. VEGF plays a central role in tumor angiogenesis and is frequently targeted in anticancer therapies. |
Research Area |
Stem Cells, Cancer, Cardiovascular, Cell Biology, Epigenetics and Nuclear Signaling, Developmental Biologys, Immunology, Drug Discovery Products, Metabolism, Neuroscience, Signal Transduction |
Storage/Stability |
The Product is shipped at ambient temperature. Upon reconstitution, the preparation is stable for up to 1 month at 2-8C. For long term storage, apportion the reconstituted preparation into working aliquots and store at -20C to -70C. Avoid repeated freeze/thaw cycles. |