Human CT-1 Antibody (1H6D4), mAb, Mouse

USA

No cross-reactivity with other proteins was detected.

Cardiotrophin-1 (CT-1) is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). It was originally isolated based on its ability to induce cardiac myocyte hypertrophy, in vitro . CT-1 has since been shown to be a pleiotrophic cytokine with overlapping actions with other IL-6 family members on a variety of cell types. Human CT-1 encodes a 201 amino acid (aa) residue protein that lacks a hydrophobic signal peptide. CT-1 is highly expressed in heart, skeletal muscle, liver, lung, and kidney. Lower level of CT-1 expression is also seen in testis and brain. CT-1 initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor beta subunit. A third alpha receptor subunit has recently been implicated in the receptor complex. GenScript Human CT-1 Antibody (1H6D4), mAb, Mouse, is produced from the hybridoma resulting from fusion of Sp2/0 myeloma and lymphocytes obtained from mouse immunized with purified full length human recombinant CT-1 protein (Swiss Prot: Q16619).

purified full length human recombinant CT-1 protein (Swiss Prot: Q16619)

Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/ml.