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ABCA1 Antibody, mAb, Mouse

ABCA1 Antibody, mAb, Mouse

ArtNr	A00121
Hersteller	GenScript
Menge	100 ug
Kategorie	Oncology Neuroscience Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Antibodies By Cell Type Hematology Lymphoma Lipoprotein Receptors & Associated Proteins Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB, IP, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Chicken (Gallus gallus domesticus)
Host	Mouse
Isotype	IgG1
Konjugat/Tag	Unconjugated
Citations	Frank PG, et al . Caveolin-1 and regulation of cellular cholesterol homeostasis. Am. J. Physiol. Heart Circ. Physiol. Aug 2006, 291(2): H677-686.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	A00121-ABCA1_Antibody_mAb_Mouse,Mouse Anti-ABCA1 mAb, Anti ABCA1
Similar products	ABCA1
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Specificity	Recognize specifically ABCA1 from human, mouse, and chicken
Manufacturer - Isotype	Mouse monoclonal IgG1
Country of Origin	USA
Storage Conditions	The antibody will remain stable for 1 year from the date of shipment if stored at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquots will remain for three months if stored at 4C.
Manufacturer - Specificity	Recognize specifically ABCA1 from human, mouse, and chicken
Concentration	1 mg/ml in PBS, pH 7.4 with 0.05% sodium azide, frozen liquid
Description	This membrane-associated protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extracellular and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangiers disease and familial high-density lipoprotein deficiency.
Immunogen	Recombinant fragment, corresponding to amino acids 1800-2260 of Human ABCA1
Purification Method	Immunoaffinity purification
Notes	Western blot, ELISA, IP, and IHC in lipid metabolic research. Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) are associated with Tangier disease (TD). TD is an autosomal recessive disorder results from an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and disorders in cellular lipid trafficking. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 100 ug

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