APP FM Antibody (339-348), pAb, Rabbit

USA

GenScript Rabbit Anti-APP FM Polyclonal Antibody can detect endogenous level of APP FM.

Amyloid precursor protein (APP) is a type I integral membrane protein with a large N-terminal extracellular domain which can be sequentially cleaved by beta-secretase and gamma-secretase to release beta-amyloid. The extracellular deposition and accumulation of the released beta-amyloid fragments form the main components of amyloid plaques in Alzheimer’s disease. APP is also found as a truncated frameshift mutant, which results from a GA dinucleotide deletion from the normal APP gene. This abnormal protein with a molecular weight of about 38 kD has been found to accumulate in the brains of some patients with Alzheimers disease. The role of the Amyloid Precursor Protein frameshift mutant (APP FM) in Alzheimers disease is currently unknown. These abnormal proteins may accumulate and lead to cellular disturbances and neuronal degeneration. GenScript, Rabbit Anti-APP FM Polyclonal Antibody, is developed in rabbit using a synthetic peptide, RGRTSSKELA, corresponding to amino acids 339-348 of the C-terminus of human APP frameshift mutant. GenScript Rabbit Anti-APP FM Polyclonal Antibody is highly purified from rabbit antiserum by immunoaffinity chromatography.

Immunoaffinity chromatography