PKCdelta Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-PKCδ, Polyclonal Antibody detects endogenous levels of total PKCδ, protein. No cross-reactivity to other PKC isoforms has been detected.

The protein kinase C (´ PKC ´, EC 2.7.11.13) is a cyclic nucleotide-independent enzyme that phosphorylates serine and threonine residues in many target proteins. The PKC family has been divided into three groups, differing in the enzymes' cofactor requirements: conventional (c)PKC isoforms (comprising alpha, betaI (also known as beta1), betaII (also known as beta2) and gamma), that require diacylglycerol (DAG), Ca2+, and phospholipid for activation, novel (n)PKC isoforms (comprising delta, epsilon, eta (also known as PKC-L), theta and u (the mouse homolog of human PKCu, also known as PKD)) that require DAG but not Ca2+, and atypical (a)PKC isoforms, namely zeta, iota and lambda (the mouse homolog of human PKCiota) that require neither Ca2+ nor DAG. A new PKC member has recently been discovered and is referred to as PKCny. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKCdelta (also known as PRKCD, PKC delta) is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. GenScript, Rabbit Anti-PKCdelta Polyclonal Antibody, is developed in rabbit using a synthetic peptide (KLH-coupled) derived from human PKCdelta.

Immunoaffinity chromatography