SAA1 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-SAA1 Polyclonal Antibody detects recombinant human SAA1 protein. Predicted to react with mouse, rat and bovine SAA1 according to sequence homology.

The serum amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAAs (C-SAAs). Although the liver is the primary site of synthesis of both SAA types, extrhepatic production has been reported. The in vivo concentrations of SAA increase by as much as 1000 fold during inflammation. Several studies have expressed SAAs importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations. SAA rises earlier and more sharply than CRP. SAA enhances the binding of HDLs to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease process. In addition, recent experiments suggest that SAA may play a housekeeping role in normal human tissues. Elevated level of SAA over time predisposes secondary amyloidosis and extracellular accumulation of amyloid fibrils which are derived from a circulating precursor in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid arthritis. GenScript, Rabbit Anti-SAA1 Polyclonal Antibody, is developed in rabbit using a synthetic peptide (KLH-coupled) derived from human SAA1.

Immunoaffinity chromatography