Amyloid Precursor Protein Antibody (Ab-730), pAb, Rabbit

USA

GenScript Rabbit Anti-Amyloid Precursor Protein (Ab-730) Polyclonal Antibody can detect endogenous level of mouse APP. Predicted to react with human, rat and bovine APP according to sequence homology.

Amyloid precursor protein (APP) is a type I integral membrane protein with a large N-terminal extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. APP can be sequentially cleaved by beta-secretase and gamma-secretase to release beta-amyloid, which is the main component of senile plaque in patient brains inflicted with Alzheimer's disease. GenScript, Rabbit Anti-Amyloid Precursor Protein (Ab-730) Polyclonal Antibody, is developed in rabbit using the synthesized peptide derived from human APP around the phosphorylation site of serine 730 (Y-T-SP-I-H). This polyclonal antibody is highly purified from rabbit antiserum by immunoaffinity chromatography and is supplied as a 40 ug aliquot at a concentration of 0.5 mg/ml.

Immunoaffinity chromatography

110 kD