CCR4 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-CCR4 Polyclonal Antibody detects human endogenous CCR4 protein. It has not yet been tested in other species.

CCR4 belongs to the G-protein-coupled receptor family. It is a receptor for C-C chemokine - MIP-1, RANTES, TARC, and MCP-1. Chemokines are small polypeptides that regulate the movements of various types of leukocytes. Not only do chemokines play fundamental roles in development, homeostasis, and immune system function, they also have effects on endothelial cells involved in angiogenesis or angiostasis and on the cells of the central nervous system. CCR4 is preferentially expressed on type 2 helper T (Th2-type) cells. Unlike that of other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. GenScript, Rabbit Anti-CCR4 Polyclonal Antibody, is developed in rabbit hosts using a synthetic peptide (KLH-coupled) corresponding to the N-terminus of human CCR4 (Accession number: P51679).

Immunoaffinity chromatography

42 kD

Small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. Before use, briefly centrifuge the vial to dislodge any liquid in the container's cap.