CCR5 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-CCR5 Polyclonal Antibody detects human CCR5 protein. It has not yet been tested for other species.

The CC chemokine receptor 5 (CCR5) is a member of the CC chemokine receptor family. It has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 is a receptor for a number of inflammatory CC chemokines including MIP-1-alpha, MIP-1-beta and RANTES. It transduces a signal by increasing the intracellular calcium ion level and may play a role in the control of granulocytic lineage proliferation or differentiation. It also acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. CCR5 is highly expressed in spleen, thymus, and also in the myeloid cell line THP-1, the promyeloblastic cell line KG-1A and on the CD4+ and CD8+ T-cells. Moreover, recent studies have highlighted the role of CCR5 in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer. GenScript, Rabbit Anti-CCR5 Polyclonal Antibody, is developed in rabbit using a KLH-coupled synthetic peptide derived from extracellular domain of human CCR5.

Immunoaffinity chromatography

Small volume of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. Before use, briefly centrifuge the vial to dislodge any liquid in the container's cap.