DJ-1 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-DJ-1 Polyclonal Antibody detects endogenous levels of human and mouse DJ-1 protein. Sequence homology predicts that it will also react with rat DJ-1 protein

DJ-1 belongs to the C56 peptidase family. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone and a sensor for oxidative stress. It apparently protects neurons against oxidative stress and cell death. Defects in PARK7 gene cause autosomal recessive early-onset Parkinson disease 7. Specifically, defects in PARK7 are characterized by PD onset before the age of 40, slow progression of the condition, and initial good response to levodopa. Parkinsons disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. However, cases of early-onset PD are sometimes found. PD generally arises as a sporadic condition but can be inherited as a simple Mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at an earlier age and are associated with atypical clinical features. PD is characterized by bradykinesia, resting tremors, muscular rigidity, and postural instability as well as by a significant clinical response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of protein aggregates) in surviving neurons at various areas of the brain. GenScript, Rabbit Anti-DJ-1 Polyclonal Antibody, is developed in rabbit using a KLH-coupled synthetic peptide within residues 50-100 of human DJ-1 protein (Swiss Prot: Q99497).

Immunoaffinity chromatography

24 kD