Rab5 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-Rab5 Polyclonal Antibody detects endogenous levels of human, mouse and rat Rab5 protein.

Small GTPase Rab5 is a member of Rab family which binds to GTP and exhibits GTPase activity. Rab5 protein is a rate-limiting component of the machinery regulating the kinetics of membrane traffic in the early endocytic pathway. Rabaptin-5 serves as an effector of Rab5 and mediates the tuberin association with Rab5. RNTRE protein whose activity is regulated by EGFR activates Rab5 GTPase. RNTRE acts on Rab5 and inhibits EGFRs internalization. The ALS2 protein specifically binds to Rab5 and functions as a guanine nucleotide exchange factor (GEF) for Rab5. As a key regulator of endocytosis, signal transduction, and mitogenesis, Rab5 protein is also a signaling GTPase that elucidates the major molecular elements of its downstream pathway. GenScript, Rabbit Anti-Rab5 Polyclonal Antibody, is developed in rabbit using a KLH-coupled synthetic peptide from within residues 150-200 of human Rab5 protein (Swiss Prot: P20339).

Immunoaffinity chromatography

24 kD