FOXA1 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-FOXA1 Polyclonal Antibody detects endogenous levels of human and mouse FOXA1 protein. It is predicted to react with rat FOXA1 protein according to sequence homology. This antibody also recognizes FOXA3.

Forkhead box protein A1 (FOXA1) is an evolutionarily conserved winged helix transcription factor that was traditionally considered to be involved in embryonic development and cell differentiation. It plays a pro-apoptotic role by inhibiting the expression of anti-apoptotic gene bcl2. FOXA1 plays a critical role in defining the ERalpha cistrome in MCF7 cells. It may serve as a therapeutic target for breast cancer. Despite the ability of FOXA1 to bind nucleosomes, its differential binding to chromatin sites is dependent on the distribution of histone H3 lysine 4 dimethylation. In addition, FOXA1 regulate multiple phases of midbrain dopaminergic neuron development. GenScript, Rabbit Anti-FOXA1 Polyclonal Antibody, is developed in rabbit using a KLH-coupled synthetic peptide from within residues 200-250 of human FOXA1 (Swiss Prot: P55317).

Immunoaffinity chromatography

Small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. Before use, briefly centrifuge the vial to dislodge any liquid in the container's cap.