p35 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-p35 Polyclonal Antibody detects endogenous levels of mouse and rat p35. It is predicted to react with human p35 according to sequence homology. Positive Control: mouse brain, and rat brain.

Cyclin-dependent kinase 5 (Cdk5) is a member of the Cdk family of proteins that are involved in the regulation of the mitotic cell cycle. p35 protein is neuronal-specific regulatory subunit of Cdk5 and activates Cdk5 via its direct interaction. p35/Cdk5 activity is essential for neuronal morphogenesis and survival. p35 is cleaved by the Ca2+ dependent Cys protease calpain, which results in the generation of a C-terminal truncation product named p25. Containing all elements necessary for the activation of Cdk5, p25 activates Cdk5. Generation of p25 in the nervous system has been implicated in patients with Alzheimer’s disease. It is suggested that p25/Cdk5 contributes to neuronal cell death after neurotoxic insults. GenScript, Rabbit Anti-p35 Polyclonal Antibody, is developed in rabbit using a KLH-coupled synthetic peptide from N-terminal of human p35 protein (Swiss Prot: Q15078).

Immunoaffinity chromatography