Neuron specific beta-Tubulin III Antibody, pAb, Rabbit

USA

GenScript, Neuron Specific beta-Tubulin III Antibody, pAb, Rabbit, detects endogenous levels of human, mouse, and rat neuron specific beta-Tubulin III and does not cross-react with other beta tubulin isotypes. Positive Control: Mouse brain, rat brain, SY-SH5H and U251.

Neuron specific beta-Tubulin III, also known as tubulin beta-4, belongs to the tubulin family. It is the major constituent of microtubules and forms dimers of alpha and beta chains. One mole of tubulin binds to two moles of GTP, one binding is an exchangeable site of the beta chain and the other is at a non exchangeable site of the alpha chain. Neuron specific beta-Tubulin III is regarded as a neuron-specific marker. The expression of neuron specific beta-Tubulin III has been implicated in signal neuronal commitment in primitive neuroepithelium. In addition, increased expression of neuron specific beta-Tubulin III occurs during cancer formation which leads to the development of anti-tubulin drugs. GenScript, Neuron Specific beta-Tubulin III Antibody, pAb, Rabbit, is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human neuron specific beta-Tubulin III (Swiss Prot: Q13509). This antibody label neuronal cell bodies, dendrites, axons, and axonal terminations and is used identify newly committed neurons. In addition, it serves an excellent loading control when normalizing data specifically for neuronal expression.

Immunoaffinity chromatography

50 KD