Mouse Epoc-1 Antibody (39F11), mAb, Mouse

USA

The lyophilized product remains stable up to 1 year at -20 C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 C or for up to 12 months at -20 C or below. Avoid freeze/thaw cycles.

POU2F3 (POU Class 2 Homeobox 3) encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for POU2F3. Epoc-1 binds to the octamer motif (5-ATTTGCAT-3). It is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. Epoc-1 is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer.