HYDb Uty

ArtNr	RP20231
Hersteller	GenScript
Menge	1 mg
Kategorie	Oncology Infectious Diseases Viral Infections Coronavirus (COVID-19) By Cell Type Carcinoma Melanoma Peptides & Proteins Adenocarcinoma Peptides By Organ Bone Cancer
Typ	Peptides
Specific against	other
Purity	> 95%
Sequence	WMHHNMDLI ; {Trp}{Met}{His}{His}{Asn}{Met}{Asp}{Leu}{Ile}
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	peptide/RP20231-HYDb_Uty, Induction of antigen-specific tolerance to transplantation antigens is desirable to control host-versus-graft and graft-versus-host reactions. Intranasal administration of individual major histocompatibility complex (MHC) class II-restricted HY peptides induces indefinite survival of syngeneic male skin grafts and allows engraftment of male bone marrow. Humans make male-specific T-cell responses to HY peptides from the same genes, SMCY, UTY, and DBY, strongly conserved across mammalian species, and from additional ubiquitously transcribed human Y chromosome genes, RPS4Y and DFFRY.Using immature, bone marrow–derived dendritic cells (BMDCs) pulsed with the immunodominant MHC class I (H2Db)–restricted HY peptide, WMHHNMDLI, encoded by the Uty gene, (HYDbUty) to induce tolerance to syngeneic male skin grafts in H2b mice. </td></tr><tr><th>Purity</th><td colspan="7"> > 95% </td></tr><tr><th>Storage</th><td colspan="7"> Store at -20C. Keep tightly closed. Store in a cool dry place. </td></tr>
Similar products	HYDb
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Country of Origin	USA
Storage Conditions	Store at -20C. Keep tightly closed. Store in a cool dry place.
Description	Induction of antigen-specific tolerance to transplantation antigens is desirable to control host-versus-graft and graft-versus-host reactions. Intranasal administration of individual major histocompatibility complex (MHC) class II-restricted HY peptides induces indefinite survival of syngeneic male skin grafts and allows engraftment of male bone marrow. Humans make male-specific T-cell responses to HY peptides from the same genes, SMCY, UTY, and DBY, strongly conserved across mammalian species, and from additional ubiquitously transcribed human Y chromosome genes, RPS4Y and DFFRY.Using immature, bone marrow–derived dendritic cells (BMDCs) pulsed with the immunodominant MHC class I (H2Db)–restricted HY peptide, WMHHNMDLI, encoded by the Uty gene, (HYDbUty) to induce tolerance to syngeneic male skin grafts in H2b mice.

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Menge: 1 mg

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