VEGI, Human

Although lyophilized VEGI-192 can remain stable at room temperature for up to three weeks, it is best stored desiccated below -18C. After reconstitution, VEGI-192 may be stored at 4C for up to seven days and below -18C for longer periods. For long-term storage, it is recommended that a carrier protein (0.1% HSA or BSA) be added. Please avoid freeze-thaw cycles.

Cytokine, Chemokines & Growth Factors

Vascular endothelial growth inhibitor (VEGI, TNFSF-15) is a new member of the tumor necrosis factor family. VEGI is predominantly an endothelial cell-specific gene, and recombinant VEGI is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. VEGI exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli, and programmed death of proliferating cells. These activities are highly specific to endothelial cells. VEGI is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that VEGI functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature. GenScript, Vascular Endothelial Growth Inhibitor (VEGI), human , produced in, E. coli , is a single, non-glycosylated polypeptide chain containing 192 amino acids and having a molecular mass of 21, 858 Da.

GenScript Recombinant Human VEGI-192 is lyophilized after extensive dialysis against 0.5 M NaCl, 50 mM Tris-HCl buffer, pH 7.5.