Human Albumin

ArtNr	18-272-197719
Hersteller	GENWAY
Menge	1 ml
Kategorie	Oncology Antibodies Primary Antibodies By Organ Hepatic Cancer
Typ	Antibody
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-39EE57
Similar products	18-272-197719
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Genway ID:	GWB-39EE57
Isotype:	IgG
Immunogen:	Human serum albumin purified from Cohn Fraction V.
Antigen Species:	Human
Specificity:	This product gives a single arc when tested by IEP and 2D-IEP against human serum. Identity is confirmed by double diffusion (Ouchterlony) vs human plasma and a known anti-human albumin
Target:	Human Albumin
Localization:	Secreted
Concentration:	18. 17 mg/ml Storage
Buffer:	Glycine buffered saline pH7. 4 0. 1% Sodium Azide 0. 1% EACA 0. 01% Benzamidine 1mM EDTA
Application Note:	RID and Rocket IEP: 2µ L antiserum/cm? gel vs 5µ L 1/200 - 1/2000 dilution human serumDouble dif
Fusion:	10µ L antiserum vs 5µ L serum (1/20 dilution)IEP: 100µ L antiserum vs 1µ L serumThe use of 3% PEG 6000 with 1. 2%agarose in a suitable buffer (such as TBE or Tris-barbital pH > 8. 2) is recommended. Suitability for use in nephelometry immunohistochemical procedures enzyme-linked immunosorbentassays and Western blot has not been assessed but use in such assays should not necessarily beexcluded. Cellular
Localization:	Secreted Serum albumin a globular unglycosylated protein of molecular weight 65 kDa is the main protein of plasma has a good binding capacity for water Ca2+ Na+ K+ fatty acids hormones bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product proalbumin is in turn cleaved in the Golgi vesicles to give the secreted albumin.
Function:	Serum albumin the main protein of plasma has a good binding capacity for water Ca(2+) Na(+) K(+) fatty acids hormones bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood.
Subcellular Location:	Secreted.
Tissue Specificity:	Plasma.
Ptm:	Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.
Ptm:	Glycated in diabetic patients.
Polymorphism:	The sequence shown is that of variant albumin A.
Disease:	Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.
Disease:	A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood [MIM:194470].
Miscellaneous:	Acetylated on Lys-223 by acetylsalicylic acid.
Similarity:	Belongs to the ALB/AFP/VDB family.
Similarity:	Contains 3 albumin domains.

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