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Rabbit anti Human NPR-B (a.a. 288-302)

Rabbit anti Human NPR-B (a.a. 288-302)

Catalytic
ArtNr	18-511-244549
Hersteller	GENWAY
Menge	0.02 ml
Kategorie	Antibodies Western Blot Cardiovascular Research Hypertension Primary Antibodies
Typ	Antibody
Applikationen	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-6C05D4
Similar products	18-511-244549
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Genway ID:	GWB-6C05D4
Host Animal:	Rabbit
Immunogen:	Synthetic human NPR-B (a. a. 288-302) poly Lys. conjugated (QNRLLIRAREDFGVE).
Specificity:	Natriuretic Peptide Receptor B (NPR-B) (a. a. 288-302)
Specificity:	Synthetic human NPR-B peptide (a. a. 288-302)
Type of Product:	Polyclonal Antibodies to Cardiac Markers
Buffer:	Not applicableApplications Notes : Suitable for use in Western blot (1:10 000). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. Rabbit anti Human NPR-B (a. a. 288-302). Rabbit Antibody to Human Natriuretic Peptide Receptor B (NPR-B) (amino acids 288-302)
Function:	Receptor for atrial natriuretic peptide (ANP) brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). Has guanylate cyclase activity on binding of ligand. The activation order seems to be CNP & gt; BNP & gt; ANP.
Activity:	GTP = 3\' 5\' -cyclic GMP + diphosphate.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Ptm:	Phosphorylation of the protein kinase-like domain is required for full activation by CNP (By similarity).
Disease:	Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature very short limbs and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth.
Miscellaneous:	There seem to be at least three natriuretic peptide hormone receptors: two with guanylate cyclase activity (NPR1/ANP-A and NPR2/ANP-B) and one (NPR3/ANP-C) which is probably responsible for the clearance of natriuretic peptides from the circulation without a role in signal transduction.
Similarity:	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Similarity:	Contains 1 guanylate cyclase domain.
Similarity:	Contains 1 protein kinase domain.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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