Goat anti Human C4

ArtNr	18-511-245559
Hersteller	GENWAY
Menge	1mg
Kategorie	Oncology Antibodies Primary Antibodies By Organ Skin Cancer
Typ	Antibody
Specific against	Human (Homo sapiens)
Host	Goat
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-43762B
Similar products	18-511-245559
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Genway ID:	GWB-43762B
Host Animal:	Goat
Immunogen:	Purified human C4
Specificity:	Complement C4
Specificity:	Monospecific by Immunoelectrophoresis (IEP) against normal human plasma and 2X concentrated normal human serum.
Type of Product:	Polyclonal Antibodies to Proteins and Bioactive Peptides
Concentration:	Lot specific OD280nm Units/mlPreservatives: NaN3
Buffer:	0. 05M Tris 0. 5M Sodium Chloride pH 7. 5Applications Notes : Specific methodologies have not been tested using this product.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. Goat anti Human C4. Goat Antibody to Human Complement Component 4. Turbidimetric Grade
Function:	C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway.
Function:	Derived from proteolytic degradation of complement C4 C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Subunit:	Circulates in blood as a disulfide-linked trimer of an alpha beta and gamma chain.
Subcellular Location:	Secreted.
Ptm:	Prior to secretion the single-chain precursor is enzymatically cleaved to yield the non-identical chains (alpha beta and gamma). During activation the alpha chain is cleaved by C1 into C4a and C4b and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.
Polymorphism:	Human complement component C4 is polymorphic at two loci C4A and C4B. 13 alleles of C4A and 22 alleles of C4B have been detected. The allele shown here is C4A4. The C4A alleles carry the Rodgers (Rg) while the C4B alleles carry the Chido (Ch) blood group antigens.
Disease:	Defects in C4A are the cause of C4A deficiency [MIM:120810].
Disease:	The C4A6 allotype is totally deficient in hemolytic activity.
Miscellaneous:	C4A allotypes react more rapidly with the amino group of peptide antigens while C4B allotypes react more rapidly with the hydroxyl group of carbohydrate antigens.
Similarity:	Contains 1 anaphylatoxin-like domain.
Similarity:	Contains 1 NTR domain.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 1mg

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