GOAT ANTI HUMAN CD289 (N-TERMINAL)

GWB-2839C8

Polyclonal IgGSpecies Cross Reactivity: Reacts with: MouseN. B. Antibody reactivity and working conditions may vary between species.

Specifically recognises an epitope within the N-terminal (NT) region of CD289 otherwise known as Toll-like receptor 9 (TLR9) a type I transmembrane glycoprotein and member of the toll-like receptor family which triggers MyD88 and TRAF6 resulting in NF-kappaB activation cytokine secretion and the inflammatory response. CD289 acts as a receptor for unmethylated cytidine-phosphate-guanosine dinucleotides in bacterial DNA (CpG-DNA) playing a primary role in pathogen recognition and activation of innate immunity.

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6 leading to NF-kappa-B activation cytokine secretion and the inflammatory response By similarity. Ref. 9Subunit structureInteracts with MYD88 via their respective TIR domains By similarity. Interacts with CNPY3 By similarity. Interacts (via transmembrane domain) with UNC93B1 By similarity. Subcellular locationEndoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Endosome By similarity. Lysosome By similarity. Cytoplasmic vesicle & rsaquo; phagosome By similarity.

a type II membrane glycoprotein involved in normal and neoplastic cell growth. \" Quackenbush E. Clabby M. Gottesdiener K. M. Barbosa J. Jones N. H. Strominger J. L. Speck S. Leiden J. M. Proc. Natl. Acad. Sci. U. S. A. 84:6526-6530(1987) [PubMed: 3476959] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). [2] ErratumQuackenbush E. Clabby M. Gottesdiener K. M. Barbosa J. Jones N. H. Strominger J. L. Speck S. Leiden J. M. Proc. Natl. Acad. Sci. U. S. A. 84:8618-8618(1987)Cited for: SEQUENCE REVISION. [3] \" Primary structure of the human 4F2 antigen heavy chain predicts a transmembrane protein with a cytoplasmic NH2 terminus. \" Teixeira S. di Grandi S. Kuehn L. C. J. Biol. Chem. 262:9574-9580(1987) [PubMed: 3036867] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). [4] \" Cloning sequence analysis and expression of the large subunit of the human lymphocyte activation antigen 4F2. \" Lumadue J. A. Glick A. B. Ruddle F. H. Proc. Natl. Acad. Sci. U. S. A. 84:9204-9208(1987) [PubMed: 3480538] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) TISSUE SPECIFICITY INDUCTION. Tissue: Fibroblast. [5] \" Isolation and structural characterization of the human 4F2 heavy-chain gene an inducible gene involved in T-lymphocyte activation. \" Gottesdiener K. M. Karpinski B. A. Lindsten T. Strominger J. L. Jones N. H. Thompson C. B. Leiden J. M. Mol. Cell. Biol. 8:3809-3819(1988) [PubMed: 3265470] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] ALTERNATIVE SPLICING (ISOFORM 2) TISSUE SPECIFICITY INDUCTION. [6] \" Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. \" Yanagida O. Kanai Y. Chairoungdua A. Kim D. K. Segawa H. Nii T. Cha S. H. Matsuo H. Fukushima J. Fukasawa Y. Tani Y. Taketani Y. Uchino H. Kim J. Y. Inatomi J. Okayasu I. Miyamoto K. Takeda E. Goya T. Endou H. Biochim. Biophys. Acta 1514:291-302(2001) [PubMed: 11557028] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) FUNCTION SUBUNIT TISSUE SPECIFICITY. Tissue: Placenta. [7] \" Human chromosome 11 DNA sequence and analysis including novel gene identification. \" Taylor T. D. Noguchi H. Totoki Y. Toyoda A. Kuroki Y. Dewar K. Lloyd C. Itoh T. Takeda T. Kim D. -W. She X. Barlow K. F. Bloom T. Bruford E. Chang J. L. Cuomo C. A. Eichler E. FitzGerald M. G. Jaffe D. B. LaButti K. Nicol R. Park H. -S. Seaman C. Sougnez C. Yang X. Zimmer A. R. Zody M. C. Birren B. W. Nusbaum C. Fujiyama A. Hattori M. Rogers J. Lander E. S. Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] ALTERNATIVE SPLICING (ISOFORM 4). [8] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Lung and Placenta. [9] Bienvenut W. V. Lao L. Ryan K. L. Submitted (OCT-2009) to UniProtKBCited for: PROTEIN SEQUENCE OF 1-17; 146-171; 227-245; 304-313; 440-451; 511-525 AND 593-630 ACETYLATION AT MET-1 MASS SPECTROMETRY. Tissue: Cervix carcinoma. [10] Strausberg R. L. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-209 (ISOFORM 4). Tissue: Lung carcinoma.