CHICKEN ANTI HUMAN ELONGIN C

ELONGIN C

TRIS buffered saline

GST-Elongin C

SIII also known as elongin is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits like VHL and members of the SOCS box family to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. Subunit structureHeterotrimer of an A (A1 A2 or A3) B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2 RBX1 and a substrate adapter protein that can be either SOCS1 TCEB3 VHL or WSB1 By similarity. The elongin BC complex is part of a complex with hydroxylated HIF1A. Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Interacts with TMF1. Interacts with human respiratory syncytial virus (HRSV) protein NS1. Ref. 3Ref. 5Ref. 6Ref. 7Subcellular locationNucleus Probable. Tissue specificityOverexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3. Ref. 4Sequence similaritiesBelongs to the SKP1 family. [1] \" Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens. \" Streuli M. Hall L. R. Saga Y. Schlossman S. F. Saito H. J. Exp. Med. 166:1548-1566(1987) [PubMed: 2824653] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) ALTERNATIVE SPLICING. Tissue: Lymphocyte. [2] \" Structural variants of human T200 glycoprotein (leukocyte-common antigen). \" Ralph S. J. Thomas M. L. Morton C. C. Trowbridge I. S. EMBO J. 6:1251-1257(1987) [PubMed: 2956090] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) ALTERNATIVE SPLICING. [3] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizushima-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K. Okumura K. Nagase T. Nomura N. Kikuchi H. Masuho Y. Yamashita R. Nakai K. Yada T. Nakamura Y. Ohara O. Isogai T. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Synovium. [4] \" Integrity of the exon 6 sequence is essential for tissue-specific alternative splicing of human leukocyte common antigen pre-mRNA. \" Tsai A. Y. M. Streuli M. Saito H. Mol. Cell. Biol. 9:4550-4555(1989) [PubMed: 2531281] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 146-192. [5] \" Complete exon-intron organization of the human leukocyte common antigen (CD45) gene. \" Hall L. R. Streuli M. Schlossman S. F. Saito H. J. Immunol. 141:2781-2787(1988) [PubMed: 2971730] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 191-1304. Tissue: Placenta. [6] \" The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase. \" Charbonneau H. Tonks N. K. Walsh K. A. Fischer E. H. Proc. Natl. Acad. Sci. U. S. A. 85:7182-7186(1988) [PubMed: 2845400] [Abstract]Cited for: FUNCTION. [7] \" Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR. \" Streuli M. Krueger N. X. Thai T. Tang M. Saito H. EMBO J. 9:2399-2407(1990) [PubMed: 1695146] [Abstract]Cited for: MUTAGENESIS. [8] \" SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription. \" Wu L. Fu J. Shen S. -H. Mol. Cell. Biol. 22:2673-2686(2002) [PubMed: 11909961] [Abstract]Cited for: INTERACTION WITH SKAP1 MUTAGENESIS OF CYS-851 FUNCTION. [9] \" A role for interleukin-12 in the regulation of T cell plasma membrane compartmentation. \" Salgado F. J. Lojo J. Alonso-Lebrero J. L. Lluis C. Franco R. Cordero O. J. Nogueira M. J. Biol. Chem. 278:24849-24857(2003) [PubMed: 12676959] [Abstract]Cited for: INTERACTION WITH DPP4 SUBCELLULAR LOCATION. [10] \" Large-scale characterization of HeLa cell nuclear phosphoproteins. \" Beausoleil S. A. Jedrychowski M. Schwartz D. Elias J. E. Villen J. Li J. Cohn M. A. Cantley L. C. Gygi S. P. Proc. Natl. Acad. Sci. U. S. A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract]Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-995; SER-1003 AND SER-1007 MASS SPECTROMETRY. Tissue: Cervix carcinoma.