RABBIT ANTI HUMAN ACTIN BETA

GWB-D80D28

Polyclonal IgGSpecies Cross Reactivity: Based on sequence similarity is expected to react with:BroadN. B. Antibody reactivity and working conditions may vary between species.

Recognises Beta Actin (ACTB) a 41. 7 kDa cytoskeletal protein. Actins are highly conserved proteins that are involved in cell motility structure and integrity and are ubiquitously expressed in all eukaryotic cells. Six different isoforms of Actin have been identified of these Actin beta is one of the three isoforms found in vertebrates. Defects in Actin beta are a cause of juvenile dystonia a condition that results in movement disorders due to disordered muscle tonicity abnormal posture development malformations and sensory hearing loss. Recommended Secondary Antibodies: Sheep Anti Rabbit IgGGoat Anti Rabbit IgG (Fc)Goat Anti Rabbit IgG (H/L)

Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Ref. 15Involvement in diseaseDefects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction often leading to abnormal postures. DYTJ patients manifest progressive generalized dopa-unresponsive dystonia developmental malformations and sensory hearing loss. Ref. 20Miscellaneous: In vertebrates 3 main groups of actin isoforms alpha beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Sequence similaritiesBelongs to the actin family. 1. Tachibana M. et al. (2000) Coreceptor function of mutant human CD4 molecules without affinity to gp120 of Human Imunodeficiency Virus. J. Biol. Chem. 275:20288-20294. 2. Abrams J. et al. (1992) Strategies of anti-cytokine monoclonal antibody development: Immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5-24. [1] \" Organization and structure of the mouse interleukin-2 gene. \" Fuse A. Fujita T. Yasumitsu H. Kashima N. Hasegawa K. Taniguchi T. Nucleic Acids Res. 12:9323-9331(1984) [PubMed: 6240025] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c. [2] \" Unique structure of murine interleukin-2 as deduced from cloned cDNAs. \" Kashima N. Nishi-Takaoka C. Fujita T. Taki S. Yamada G. Hamuro J. Taniguchi T. Nature 313:402-404(1985) [PubMed: 2578624] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: B10BR. [3] \" Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells. \" Yokota T. Arai N. Lee F. Rennick D. Mosmann T. Arai K. Proc. Natl. Acad. Sci. U. S. A. 82:68-72(1985) [PubMed: 3918306] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. [4] \" Cloning and structure of a mouse interleukin-2 chromosomal gene. \" Degrave W. Simons G. Devos R. Plaetinck G. Remaut E. Tavernier J. Fiers W. Mol. Biol. Rep. 11:57-61(1986) [PubMed: 3003564] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [5] \" Congenic mapping of the type 1 diabetes locus Idd3 to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. \" Lyons P. A. Armitage N. Argentina F. Denny P. Hill N. J. Lord C. J. Wilusz M. B. Peterson L. B. Wicker L. S. Todd J. A. Genome Res. 10:446-453(2000) [PubMed: 10779485] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6. [6] Ma R. Z. Teuscher C. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Spleen. [7] \" Lineage-specific biology revealed by a finished genome assembly of the mouse. \" Church D. M. Goodstadt L. Hillier L. W. Zody M. C. Goldstein S. She X. Bult C. J. Agarwala R. Cherry J. L. DiCuccio M. Hlavina W. Kapustin Y. Meric P. Maglott D. Birtle Z. Marques A. C. Graves T. Zhou S. Teague B. Potamousis K. Churas C. Place M. Herschleb J. Runnheim R. Forrest D. Amos-Landgraf J. Schwartz D. C. Cheng Z. Lindblad-Toh K. Eichler E. E. Ponting C. P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J. [8] \" A new cDNA sequence for the murine interleukin-2 gene. \" Matesanz F. Alcina A. Pellicer A. Biochim. Biophys. Acta 1132:335-336(1992) [PubMed: 1420317] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-63. Strain: RF. Tissue: Spleen. [9] \" Existence of at least five interleukin-2 molecules in different mouse strains. \" Matesanz F. Alcina A. Pellicer A. Immunogenetics 38:300-303(1993) [PubMed: 8319981] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-63. Strain: CAST/Ei and RF/J. Tissue: Spleen. [10] \" Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor. \" Zurawski S. Vega F. Jr. Doyel E. L. Huyghe B. Flaherty K. McKay D. B. Zurawski G. EMBO J. 12:5113-5119(1993) [PubMed: 8262055] [Abstract]Cited for: 3D-STRUCTURE MODELING.