GOAT ANTI HUMAN C-REACTIVE PROTEIN

C-REACTIVE PROTEIN

Phosphate buffered saline pH7. 4

Native

Displays several functions associated with host defense: it promotes agglutination bacterial capsular swelling phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Cofactor: Binds 2 calcium ions per subunit. Subunit structureHomopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Subcellular locationSecreted. Tissue specificityFound in plasma.

This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium. Sequence similaritiesBelongs to the pentaxin family. Contains 1 pentaxin domain. Mass spectrometryMolecular mass is 23028 Da from positions 19 - 224. Determined by MALDI. Ref. 14Molecular mass is 22930 Da from positions 19 - 223. Determined by MALDI. Ref. 14 1. Harris J. L. et al. (2009) Aprataxin poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage. Hum Mol Genet. 18: 4102-17. 2. Freire R. et al. (2001) Cleavage of the Bloom\' s syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha. Nucleic Acids Res. 29: 3172-3180. 3. Krohn A. et al. (1998) Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector. J. Neurosci. 18: 8186-8197. 4. Staples C. J. et al. (2010) Crosstalk between the p38{alpha} and JNK MAP kinase pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation. J Biol Chem. Jun 11. [Epub ahead of print] [1] \" Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase. \" Uchida K. Morita T. Sato T. Ogura T. Yamashita R. Noguchi S. Suzuki H. Nyunoya H. Miwa M. Sugimura T. Biochem. Biophys. Res. Commun. 148:617-622(1987) [PubMed: 3120710] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fibroblast. [2] \" Primary structure of human poly(ADP-ribose) synthetase as deduced from cDNA sequence. \" Kurosaki T. Ushiro H. Mitsuuchi Y. Suzuki S. Matsuda M. Matsuda Y. Katunuma N. Kangawa K. Matsuo H. Hirose T. Inayama S. Shizuta Y. J. Biol. Chem. 262:15990-15997(1987) [PubMed: 2824474] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fibroblast. [3] \" cDNA sequence protein structure and chromosomal location of the human gene for poly(ADP-ribose) polymerase. \" Cherney B. W. McBride O. W. Chen D. Alkhatib H. Bhatia K. Hensley P. Smulson M. E. Proc. Natl. Acad. Sci. U. S. A. 84:8370-8374(1987) [PubMed: 2891139] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANT ARG-940. [4] \" Human nuclear NAD+ ADP-ribosyltransferase(polymerizing): organization of the gene. \" Auer B. Nagl U. Herzog H. Schneider R. Schweiger M. DNA 8:575-580(1989) [PubMed: 2513174] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [5] NIEHS SNPs programSubmitted (JUN-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANTS THR-188; ILE-334; TYR-383; ALA-762 AND ARG-940. [6] \" The DNA sequence and biological annotation of human chromosome 1. \" Gregory S. G. Barlow K. F. McLay K. E. Kaul R. Swarbreck D. Dunham A. Scott C. E. Howe K. L. Woodfine K. Spencer C. C. A. Jones M. C. Gillson C. Searle S. Zhou Y. Kokocinski F. McDonald L. Evans R. Phillips K. Atkinson A. Cooper R. Jones C. Hall R. E. Andrews T. D. Lloyd C. Ainscough R. Almeida J. P. Ambrose K. D. Anderson F. Andrew R. W. Ashwell R. I. S. Aubin K. Babbage A. K. Bagguley C. L. Bailey J. Beasley H. Bethel G. Bird C. P. Bray-Allen S. Brown J. Y. Brown A. J. Buckley D. Burton J. Bye J. Carder C. Chapman J. C. Clark S. Y. Clarke G. Clee C. Cobley V. Collier R. E. Corby N. Coville G. J. Davies J. Deadman R. Dunn M. Earthrowl M. Ellington A. G. Errington H. Frankish A. Frankland J. French L. Garner P. Garnett J. Gay L. Ghori M. R. J. Gibson R. Gilby L. M. Gillett W. Glithero R. J. Grafham D. V. Griffiths C. Griffiths-Jones S. Grocock R. Hammond S. Harrison E. S. I. Hart E. Haugen E. Heath P. D. Holmes S. Holt K. Howden P. J. Hunt A. R. Hunt S. E. Hunter G. Isherwood J. James R. Johnson C. Johnson D. Joy A. Kay M. Kershaw J. K. Kibukawa M. Kimberley A. M. King A. Knights A. J. Lad H. Laird G. Lawlor S. Leongamornlert D. A. Lloyd D. M. Loveland J. Lovell J. Lush M. J. Lyne R. Martin S. Mashreghi-Mohammadi M. Matthews L. Matthews N. S. W. McLaren S. Milne S. Mistry S. Moore M. J. F. Nickerson T. O\' Dell C. N. Oliver K. Palmeiri A. Palmer S. A. Parker A. Patel D. Pearce A. V. Peck A. I. Pelan S. Phelps K. Phillimore B. J. Plumb R. Rajan J. Raymond C. Rouse G. Saenphimmachak C. Sehra H. K. Sheridan E. Shownkeen R. Sims S. Skuce C. D. Smith M. Steward C. Subramanian S. Sycamore N. Tracey A. Tromans A. Van Helmond Z. Wall M. Wallis J. M. White S. Whitehead S. L. Wilkinson J. E. Willey D. L. Williams H. Wilming L. Wray P. W. Wu Z. Coulson A. Vaudin M. Sulston J. E. Durbin R. M. Hubbard T. Wooster R. Dunham I. Carter N. P. McVean G. Ross M. T. Harrow J. Olson M. V. Beck S. Rogers J. Bentley D. R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [7] Mural R. J. Istrail S. Sutton G. G. Florea L. Halpern A. L. Mobarry C. M. Lippert R. Walenz B. Shatkay H. Dew I. Miller J. R. Flanigan M. J. Edwards N. J. Bolanos R. Fasulo D. Halldorsson B. V. Hannenhalli S. Turner R. Yooseph S. Lu F. Nusskern D. R. Shue B. C. Zheng X. H. Zhong F. Delcher A. L. Huson D. H. Kravitz S. A. Mouchard L. Reinert K. Remington K. A. Clark A. G. Waterman M. S. Eichler E. E. Adams M. D. Hunkapiller M. W. Myers E. W. Venter J. C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [8] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] VARIANT ALA-762. Tissue: Brain. [9] \" Human poly(ADP-ribose) polymerase gene. Cloning of the promoter region. \" Yokoyama Y. Kawamoto T. Mitsuuchi Y. Kurosaki T. Toda K. Ushiro H. Terashima M. Sumimoto H. Kuribayashi I. Yamamoto Y. Maeda T. Ikeda H. Sagara Y. Shizuta Y. Eur. J. Biochem. 194:521-526(1990) [PubMed: 2125269] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-95. [10] \" Characterization of a putative promoter region of the human poly(ADP-ribose) polymerase gene: structural similarity to that of the DNA polymerase beta gene. \" Ogura T. Nyunoya H. Takahashi-Masutani M. Miwa M. Sugimura T. Esumi H. Biochem. Biophys. Res. Commun. 167:701-710(1990) [PubMed: 2108670] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40.