SHEEP ANTI HUMAN C-REACTIVE PROTEIN

C-REACTIVE PROTEIN

Phosphate buffered saline pH7. 4

Native from serum

Displays several functions associated with host defense: it promotes agglutination bacterial capsular swelling phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Cofactor: Binds 2 calcium ions per subunit. Subunit structureHomopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Subcellular locationSecreted. Tissue specificityFound in plasma.

This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium. Sequence similaritiesBelongs to the pentaxin family. Contains 1 pentaxin domain. Mass spectrometryMolecular mass is 23028 Da from positions 19 - 224. Determined by MALDI. Ref. 14Molecular mass is 22930 Da from positions 19 - 223. Determined by MALDI. Ref. 14 1. Krohn A. et al. (1998) Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector. J. Neurosci. 18: 8186-8197. 2. Kubota M. et al. (1997) Oral immunization with Simian Immunodeficiency Virus p55 gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in non human primates. J. Immunol. 158: 5321-5329. 3. Abrams J. S. et al. (1992) Strategies of anti-cytokine monoclonal antibody development : Immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127: 5-24. 4. Patterson B. et al. (2001) Leukemia inhibitory factor inhibits HIV-1 replication and is upregulated in placentae from nontransmitting women. J. Clin. Invest. 107: 287-294. 5. Carvalho E. et al. (1994) Restoration of IFN-gamma production and lymphocyte proliferation in visceral leishmaniasis. J. Immunol. 152: 5949-5956. [1] \" Isolation and characterization of a human interleukin cDNA clone homologous to mouse B-cell stimulatory factor 1 that expresses B-cell- and T-cell-stimulating activities. \" Yokota T. Otsuka T. Mosmann T. Banchereau J. Defrance T. Blanchard D. de Vries J. E. Lee F. Arai K. Proc. Natl. Acad. Sci. U. S. A. 83:5894-5898(1986) [PubMed: 3016727] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). [2] \" Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression. \" Arai N. Nomura D. Villaret D. Malefijt R. D. Seiki M. Yoshida M. Minoshima S. Fukuyama R. Maekawa M. Kudoh J. Shimizu N. Yokota K. Abe E. Yokota T. Takebe Y. Arai K. J. Immunol. 142:274-282(1989) [PubMed: 2535858] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [3] \" An alternatively spliced interleukin 4 form in lymphoid cells. \" Klein S. C. Golverdingen J. Bouwens A. G. M. Tilanus M. G. J. Immunogenetics 41:57-57(1995) [PubMed: 7806280] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). [4] SeattleSNPs variation discovery resourceSubmitted (JUN-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [5] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Blood. [6] \" The 5\' region of the human interleukin 4 gene: structure and potential regulatory elements. \" Eder A. Krafft-Czepa H. Krammer P. H. Nucleic Acids Res. 16:772-772(1988) [PubMed: 3257560] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45. [7] \" Disulfide assignments in recombinant mouse and human interleukin 4. \" Carr C. Aykent S. Kimack N. M. Levine A. D. Biochemistry 30:1515-1523(1991) [PubMed: 1993171] [Abstract]Cited for: PARTIAL PROTEIN SEQUENCE GLYCOSYLATION AT ASN-62 DISULFIDE BONDS. [8] \" Crystal structure of recombinant human interleukin-4. \" Walter M. R. Cook W. J. Zhao B. G. Cameron R. P. Jr. Ealick S. E. Walter R. L. Jr. Reichert P. Nagabhushan T. L. Trotta P. P. Bugg C. E. J. Biol. Chem. 267:20371-20376(1992) [PubMed: 1400355] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2. 35 ANGSTROMS). [9] \" Crystal structure of human recombinant interleukin-4 at 2. 25-A resolution. \" Wlodaver A. Pavlovsky A. Gustchina A. FEBS Lett. 309:59-64(1992) [PubMed: 1511746] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2. 25 ANGSTROMS). [10] \" Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface. \" Hage T. Sebald W. Reinemer P. Cell 97:271-281(1999) [PubMed: 10219247] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2. 3 ANGSTROMS) OF 25-153 IN COMPLEX WITH IL4RALPHA.