GOAT ANTI HUMAN ANTITHROMBIN III

ANTITHROMBIN III

TRIS buffered saline pH7. 4

Purified human Antithrombin III

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Subcellular locationSecreted & rsaquo; extracellular space. Tissue specificityFound in plasma. Ref. 21Post-translational modificationPhosphorylation sites are present in the extracelllular medium. Involvement in diseaseDefects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Ref. 13Ref. 3Ref. 12Ref. 31Ref. 32Ref. 33Ref. 34Ref. 35Ref. 36Ref. 37Ref. 38Ref. 40Ref. 41Ref. 42Ref. 43Ref. 44Ref. 45Ref. 46Ref. 47Ref. 48Ref. 49Ref. 50Ref. 51Ref. 52Ref. 53Ref. 54Ref. 55Ref. 56Ref. 57Ref. 59Ref. 60Ref. 61Ref. 62Ref. 63Ref. 64Ref. 65Ref. 66Sequence similaritiesBelongs to the serpin family. Mass spectrometryMolecular mass is 57863 Da from positions 33 - 464. Determined by ESI. Ref. 13Molecular mass is 57911 Da from positions 33 - 464. Determined by ESI. Variant Thr-414. Ref. 13 1. Haruta Y. and Seon B. K. (1986) Distinct human leukemia-associated cell surface glycoprotein GP160 defined by monoclonal antibody SN6. Proc. Natl. Acad. Sci. USA 83: 7898-7902. 2. Jin H. J. et al. (2010) GD2expression is closely associated with neuronal differentiation of human umbilical cord blood-derived mesenchymal stem cells. Cell Mol Life Sci. Feb 18. [Epub ahead of print] [1] \" Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. \" Bellon T. Corbi A. Lastres P. Cales C. Cebrian M. Vera S. Cheifetz S. Massague J. Letarte M. Bernabeu C. Eur. J. Immunol. 23:2340-2345(1993) [PubMed: 8370410] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). [2] \" DNA sequence and analysis of human chromosome 9. \" Humphray S. J. Oliver K. Hunt A. R. Plumb R. W. Loveland J. E. Howe K. L. Andrews T. D. Searle S. Hunt S. E. Scott C. E. Jones M. C. Ainscough R. Almeida J. P. Ambrose K. D. Ashwell R. I. S. Babbage A. K. Babbage S. Bagguley C. L. Bailey J. Banerjee R. Barker D. J. Barlow K. F. Bates K. Beasley H. Beasley O. Bird C. P. Bray-Allen S. Brown A. J. Brown J. Y. Burford D. Burrill W. Burton J. Carder C. Carter N. P. Chapman J. C. Chen Y. Clarke G. Clark S. Y. Clee C. M. Clegg S. Collier R. E. Corby N. Crosier M. Cummings A. T. Davies J. Dhami P. Dunn M. Dutta I. Dyer L. W. Earthrowl M. E. Faulkner L. Fleming C. J. Frankish A. Frankland J. A. French L. Fricker D. G. Garner P. Garnett J. Ghori J. Gilbert J. G. R. Glison C. Grafham D. V. Gribble S. Griffiths C. Griffiths-Jones S. Grocock R. Guy J. Hall R. E. Hammond S. Harley J. L. Harrison E. S. I. Hart E. A. Heath P. D. Henderson C. D. Hopkins B. L. Howard P. J. Howden P. J. Huckle E. Johnson C. Johnson D. Joy A. A. Kay M. Keenan S. Kershaw J. K. Kimberley A. M. King A. Knights A. Laird G. K. Langford C. Lawlor S. Leongamornlert D. A. Leversha M. Lloyd C. Lloyd D. M. Lovell J. Martin S. Mashreghi-Mohammadi M. Matthews L. McLaren S. McLay K. E. McMurray A. Milne S. Nickerson T. Nisbett J. Nordsiek G. Pearce A. V. Peck A. I. Porter K. M. Pandian R. Pelan S. Phillimore B. Povey S. Ramsey Y. Rand V. Scharfe M. Sehra H. K. Shownkeen R. Sims S. K. Skuce C. D. Smith M. Steward C. A. Swarbreck D. Sycamore N. Tester J. Thorpe A. Tracey A. Tromans A. Thomas D. W. Wall M. Wallis J. M. West A. P. Whitehead S. L. Willey D. L. Williams S. A. Wilming L. Wray P. W. Young L. Ashurst J. L. Coulson A. Blocker H. Durbin R. M. Sulston J. E. Hubbard T. Jackson M. J. Bentley D. R. Beck S. Rogers J. Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [3] Mural R. J. Istrail S. Sutton G. G. Florea L. Halpern A. L. Mobarry C. M. Lippert R. Walenz B. Shatkay H. Dew I. Miller J. R. Flanigan M. J. Edwards N. J. Bolanos R. Fasulo D. Halldorsson B. V. Hannenhalli S. Turner R. Yooseph S. Lu F. Nusskern D. R. Shue B. C. Zheng X. H. Zhong F. Delcher A. L. Huson D. H. Kravitz S. A. Mouchard L. Reinert K. Remington K. A. Clark A. G. Waterman M. S. Eichler E. E. Adams M. D. Hunkapiller M. W. Myers E. W. Venter J. C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [4] \" Primary structure of endoglin an RGD-containing glycoprotein of human endothelial cells. \" Gougos A. Letarte M. J. Biol. Chem. 265:8361-8364(1990) [PubMed: 1692830] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 14-658 PROTEIN SEQUENCE OF 26-36 (ISOFORM LONG). Tissue: Umbilical vein. [5] \" Endoglin a TGF-beta binding protein of endothelial cells is the gene for hereditary haemorrhagic telangiectasia type 1. \" McAllister K. A. Grogg K. M. Johnson D. W. Gallione C. J. Baldwin M. A. Jackson C. E. Helmbold E. A. Markel D. S. McKinnon W. C. Murrell J. McCormick M. K. Pericak-Vance M. A. Heutink P. Oostra B. A. Haitjema T. Westerman C. J. Porteous M. E. Guttmacher A. E. Letarte M. Marchuk D. A. Nat. Genet. 8:345-351(1994) [PubMed: 7894484] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 122-378. [6] \" Identification of Tctex2beta a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors. \" Meng Q. -J. Lux A. Holloschi A. Li J. Hughes J. M. X. Foerg T. McCarthy J. E. G. Heagerty A. M. Kioschis P. Hafner M. Garland J. M. J. Biol. Chem. 281:37069-37080(2006) [PubMed: 16982625] [Abstract]Cited for: INTERACTION WITH TCTEX1D4. [7] \" The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells. \" Lee N. Y. Blobe G. C. J. Biol. Chem. 282:21507-21517(2007) [PubMed: 17540773] [Abstract]Cited for: INTERACTION WITH ARRB2. [8] \" Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. \" Chen R. Jiang X. Sun D. Han G. Wang F. Ye M. Wang L. Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract]Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-134 MASS SPECTROMETRY. Tissue: Liver. [9] \" Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia. \" Shovlin C. L. Hughes J. M. B. Scott J. Seidman C. E. Seidman J. G. Am. J. Hum. Genet. 61:68-79(1997) [PubMed: 9245986] [Abstract]Cited for: VARIANT HHT1 192-ARG--PRO-198 DEL VARIANT MET-5. [10] \" A novel missense mutation in the endoglin gene in hereditary hemorrhagic telangiectasia. \" Yamaguchi H. Azuma H. Shigekiyo T. Inoue H. Saito S. Thromb. Haemost. 77:243-247(1997) [PubMed: 9157574] [Abstract]Cited for: VARIANT HHT1 ASP-160.