GOAT ANTI HUMAN IgA

IgA

TRIS buffered saline pH7. 4

Purified human IgA

Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. Subunit structureMonomeric or polymeric. Post-translational modification3-Hydroxykynurenine an oxidized tryptophan metabolite that is common in biological fluids reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352. Involvement in diseaseNote=A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1; 14)(q21; q32) that forms a FCRL4-IGHA1 fusion protein. Sequence similaritiesContains 3 Ig-like (immunoglobulin-like) domains. Sequence cautionThe sequence AAC82528. 1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. 1. Jefferies W. A. et al. (1985) Analysis of lymphopoietic stem cells with a monoclonal antibody to the rat transferrin receptor. Immunology 54: 333-341. 2. Yefimova M. G. et al. (1984) Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of Surgeons rats. Inv. Opth. & Vis. Sci. 43: 537-545. 3. Jefferies W. A. et al. (1984) Transferrin receptor on endothelium of brain capillaries. Nature 312: 162-163. 4. Lipardi C. et al. (2002) Differential recognition of a tyrosine-dependent signal in the basolateral and endocytic pathways of thyroid epithelial cells. Endocrinology. 143: 1291-1301. 5. Stevenson K. S. et al. (2009) Isolation characterization and differentiation of thy1. 1-sorted pancreatic adult progenitor cell populations. Stem Cells Dev. 18: 1389-98. [1] \" Characterization of rat transferrin receptor cDNA: the regulation of transferrin receptor mRNA in testes and in Sertoli cells in culture. \" Roberts K. P. Griswold M. D. Mol. Endocrinol. 4:531-542(1990) [PubMed: 2126342] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.