GOAT ANTI HUMAN LAMBDA LIGHT CHAIN

LAMBDA LIGHT CHAIN (BOUND AND FREE)

TRIS buffered saline pH7. 4

Purified human lambda light chains

Mcg+ Kern+ and Oz-. The Mcg isotype marker is characterized by Asn-6 Thr-8 and Lys-57; the Ke marker by Gly-46 and the Oz- marker by Arg-83. Sequence similaritiesContains 1 Ig-like (immunoglobulin-like) domain. Sequence cautionThe sequence CAA36047. 1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. 1. Hermann P. et al. (1993) Expression of a 32-kDa ligand for the CD40 antigen on activated human T lymphocytes. Eur. J. Immunol. 23: 961-964. 2. Lane P. et al. (1992) Activated human T cells express a ligand for the human B cell associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes. Eur. J. Immunol. 22: 2573-2578. 3. Kroczek R. A. et al. (1994) Defective expression of CD40 ligand on T cells causes \" X-linked immunodeficiency with hyper-IgM (HIGM1)\" Immunol. Rev. 138: 39-59. [1] \" Cloning of TRAP a ligand for CD40 on human T cells. \" Graf D. Korthaeuer U. Mages H. W. Senger G. Kroczek R. A. Eur. J. Immunol. 22:3191-3194(1992) [PubMed: 1280226] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] \" The human T cell antigen gp39 a member of the TNF gene family is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. \" Hollenbaugh D. Grosmaire L. S. Kullas C. D. Chalupny J. N. Braesch-Andersen S. Noelle R. J. Stamenkovic I. Ledbetter J. A. Aruffo A. EMBO J. 11:4313-4321(1992) [PubMed: 1385114] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] \" The CD40 ligand gp39 is defective in activated T cells from patients with X-linked hyper-IgM syndrome. \" Aruffo A. Farrington M. Hollenbaugh D. Li X. Milatovich A. Nonoyama S. Bajorath J. Grosmaire L. S. Stenkamp R. Neubauer M. Roberts R. L. Noelle R. J. Ledbetter J. A. Francke U. Ochs H. D. Cell 72:291-300(1993) [PubMed: 7678782] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANTS HIGM1 128-ARG-GLY-129 AND PRO-235. [4] \" Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. \" Spriggs M. K. Armitage R. J. Strockbine L. Clifford K. N. Macduff B. M. Sato T. A. Maliszewski C. R. Fanslow W. C. J. Exp. Med. 176:1543-1550(1992) [PubMed: 1281209] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [5] \" Human CD40-ligand: molecular cloning cellular distribution and regulation of expression by factors controlling IgE production. \" Gauchat J. -F. Aubry J. -P. Mazzei G. J. Life P. Jomotte T. Elson G. Bonnefoy J. -Y. FEBS Lett. 315:259-266(1993) [PubMed: 7678552] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [6] \" Structural organization of the gene for CD40 ligand: molecular analysis for diagnosis of X-linked hyper-IgM syndrome. \" Shimadzu M. Nunoi H. Terasaki H. Ninomiya R. Iwata M. Kanegasaka S. Matsuda I. Biochim. Biophys. Acta 1260:67-72(1995) [PubMed: 7999797] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [7] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood. [8] \" Human native soluble CD40L is a biologically active trimer processed inside microsomes. \" Pietravalle F. Lecoanet-Henchoz S. Blasey H. Aubry J. -P. Elson G. Edgerton M. D. Bonnefoy J. -Y. Gauchat J. -F. J. Biol. Chem. 271:5965-5967(1996) [PubMed: 8626375] [Abstract]Cited for: PROTEIN SEQUENCE OF 113-117 PROTEOLYTIC PROCESSING. [9] \" Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells. \" Khandekar S. S. Silverman C. Wells-Marani J. Bacon A. M. Birrell H. Brigham-Burke M. DeMarini D. J. Jonak Z. L. Camilleri P. Fishman-Lobell J. Protein Expr. Purif. 23:301-310(2001) [PubMed: 11676606] [Abstract]Cited for: STRUCTURE OF CARBOHYDRATE ON ASN-240 MASS SPECTROMETRY. [10] \" Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization. \" Furman M. I. Krueger L. A. Linden M. D. Barnard M. R. Frelinger A. L. III Michelson A. D. J. Am. Coll. Cardiol. 43:2319-2325(2004) [PubMed: 15193700] [Abstract]Cited for: FUNCTION.