MOUSE ANTI HUMAN IgM:FITC

GWB-1A9CAB

IgG1

Phosphate buffered saline pH7. 4

Native IgM

IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses cellular waste and modified self as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as an homopentamer. After the antigen binds to the B-cell receptor the secreted form is secreted in large amounts. Ref. 9Subunit structureImmunoglobulin (Ig) molecules consist of two chains one heavy chain (which can be alpha delta epsilon gamma or mu) and one light chain (which can be kappa or lambda) each consisting of a variable and a constant region. An IgM molecule contains thus a mu heavy chain combined with either a kappa or a lambda light chains. It is found almost exclusively as an homopentamer in the serum. Membrane-bound IgM molecules are non-covalently associated with heterodimer of CD79A and CD79B. Subcellular locationIsoform 1: Secreted.

All 4 combinations of the S/G and V/G polymorphisms at positions 191 and 215 have been observed in human mu chains. Sequence cautionThe sequence CAA33071. 1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAA34971. 1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. [1] \" Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. \" Hu R. -M. Han Z. -G. Song H. -D. Peng Y. -D. Huang Q. -H. Ren S. -X. Gu Y. -J. Huang C. -H. Li Y. -B. Jiang C. -L. Fu G. Zhang Q. -H. Gu B. -W. Dai M. Mao Y. -F. Gao G. -F. Rong R. Ye M. Zhou J. Xu S. -H. Gu J. Shi J. -X. Jin W. -R. Zhang C. -K. Wu T. -M. Huang G. -Y. Chen Z. Chen M. -D. Chen J. -L. Proc. Natl. Acad. Sci. U. S. A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland. [2] \" Cloning of human full-length CDSs in BD Creator(TM) system donor vector. \" Kalnine N. Chen X. Rolfs A. Halleck A. Hines L. Eisenstein S. Koundinya M. Raphael J. Moreira D. Kelley T. LaBaer J. Lin Y. Phelan M. Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [3] \" The DNA sequence of human chromosome 7. \" Hillier L. W. Fulton R. S. Fulton L. A. Graves T. A. Pepin K. H. Wagner-McPherson C. Layman D. Maas J. Jaeger S. Walker R. Wylie K. Sekhon M. Becker M. C. O\' Laughlin M. D. Schaller M. E. Fewell G. A. Delehaunty K. D. Miner T. L. Nash W. E. Cordes M. Du H. Sun H. Edwards J. Bradshaw-Cordum H. Ali J. Andrews S. Isak A. Vanbrunt A. Nguyen C. Du F. Lamar B. Courtney L. Kalicki J. Ozersky P. Bielicki L. Scott K. Holmes A. Harkins R. Harris A. Strong C. M. Hou S. Tomlinson C. Dauphin-Kohlberg S. Kozlowicz-Reilly A. Leonard S. Rohlfing T. Rock S. M. Tin-Wollam A. -M. Abbott A. Minx P. Maupin R. Strowmatt C. Latreille P. Miller N. Johnson D. Murray J. Woessner J. P. Wendl M. C. Yang S. -P. Schultz B. R. Wallis J. W. Spieth J. Bieri T. A. Nelson J. O. Berkowicz N. Wohldmann P. E. Cook L. L. Hickenbotham M. T. Eldred J. Williams D. Bedell J. A. Mardis E. R. Clifton S. W. Chissoe S. L. Marra M. A. Raymond C. Haugen E. Gillett W. Zhou Y. James R. Phelps K. Iadanoto S. Bubb K. Simms E. Levy R. Clendenning J. Kaul R. Kent W. J. Furey T. S. Baertsch R. A. Brent M. R. Keibler E. Flicek P. Bork P. Suyama M. Bailey J. A. Portnoy M. E. Torrents D. Chinwalla A. T. Gish W. R. Eddy S. R. McPherson J. D. Olson M. V. Eichler E. E. Green E. D. Waterston R. H. Wilson R. K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [4] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate. [5] Colinge J. Superti-Furga G. Bennett K. L. Submitted (OCT-2008) to UniProtKBCited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].