MOUSE ANTI HUMAN CD65s

CD65s

Purified IgM prepared by ammonium sulphate precipitation.

Selectively recognises the sialylated form of human CD65 known as CD65s (VIM-2 antigen) a leucocyte carbohydrate antigen expressed by granulocytes monocytes and leukaemic cells of myelomonocytic lineage. CD65s is aberrantly expressed on some acute myeloid leukaemias (AML) and clone VIM-2 has been reliably used as a marker for distinguishing between mature and undifferentiated AML. During normal myelopoiesis expression of CD65s follows the disappearance of the progenitor antigen CD34. Cross-linking of the CD65s antigen using clone VIM-2 has been shown to induce phagocyte cytoplasmic calcium flux oxidative burst and degranulation (2). AbD Recommended Negative Controls: MOUSE IgM NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Mouse IgMGoat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgM